Assignment Example | Topics and Well Written Essays - 1000 words - 3

Assignment Example This programmed cell death is called apoptosis; where cells deliberately destroy themselves. The events around the death are controlled by the nuclear genes. It begins with the breaking of the chromosomal DNA into fragments then the breakdown of the nucleus. Ultimately after time the cell shrinks and is fed on by the neighboring cells and macrophages. Cells that are damaged for some reason like DNA alteration or infection undergo programmed death. The process removes lethal cells which could lead to undesired mutation or viral spread. The cell might as well die for reasons like starvation, trauma, or asphyxiate. (Geoffrey and Robert, 97 ) Programmed cell death plays a very major role in maintaining the life and health of organisms. It is a normal part of embryonic development. For instance, the fingers and toes of a human are webbed when in the embryonic stage. Through cell death, the webbing is removed through apoptosis. The immune and nervous systems are also largely developed thro ugh the same process. (Wayne, 24) The process of apoptosis involves a variety of intra and extra cellular stimuli. When it is induced by extra-cellular factors, it is triggered by cell surface death receptors. These death receptors have cytoplasmic death domains (FADD and TRADD). They are typified by the tumor necrosis receptor superfamily which includes tumor necrosis factor receptor 1 (TNFR-1), TNF related apoptosis – inducing ligand recptor 1 (TRAILR-1), death receptor 3ectodermal dysplasia receptor (EDAR), nerve growth receptor and the cytotoxic T-cell proteins like perforin and granzyme-B. The FAS receptor is found on the surface of the cell (on the chromosome) and it leads to programmed cell death. Apoptosis uses it as a pathway. It also uses the mitochondrial pathway (Geoffrey and Cooper, 46) Apoptosis is driven by the impetus of enzymes from the regulated family proteolytic enzymes called caspases. Caspases are made up of upstream (initiator) caspases which are normal ly activated by death receptor signalosomes, casase 9, activated by the mitochondrial cytochrome derived apoptosome; downstream caspases (effectors) which cleave the involved proteins. Interaction with death receptor cytoplasmic death inducing signaling complexes that contain FAS-associating death domain activates caspases 2, 8 and 10. The receptors are activated by ligands involved in signaling cell death hence supporting cell selection, homeostasis, and morphogenesis and host defense (Carlo, 16) Death receptor ligands include Fas ligand, tumor necrosis factor alpha, NF-related apoptosis inducing ligand, TNF-related weak inducer of apoptosis, TNF-related molecule 1 and nerve growth factor. The ligand is a homotrimetic type II transmembrane protein of the TNF family. It induces apoptosis through trimetization hence playing an important role in the regulation of immune system. It also has a role in the progression of cancer. It is the Fas ligand that forms the death inducing signalin g complex (DISC). Caspase-8 is released from DISC to the cytosol and it cleaves the other effector caspases. This leads to DNA degradation, membrane blebbing and other events that are associated with apoptosis. It is suggested that the extrinsic Fas pathway on its own can induce apoptosis in certain cell types. These cells are dubbed Type 1 cells and are characterized by the inability of the anti-apoptotic members of the Bcl-2

Assessing Learning and Achievement Essay Example | Topics and Well Written Essays - 2750 words

Assessing Learning and Achievement - Essay Example For college students I based mostly on observations, presentations and project work. The complete opposite is for work based learners where the most appropriate methods are witness testimonies, products of work and accreditation for prior learning. With regards to the issues I intend to address are as follow: The advantages and disadvantages of criterion-referenced assessment, the assessment of validity and reliability (where demand from the government to meet targets forces from the colleges, to employ assessors lacking in competence, making assessment value to be questioned). Also I would like to address the current issues in assessment policy bureaucracy, the measuring and recording of assessment results reduces time spent with the learner, 'bums on seats' model forces colleges to accumulate quantitative achievement rather than qualitative ones. As result this makes the value of qualifications and achievement questionable. In the initial assessment, computer tests are used to identify the literacy and numercacy level of potential applicants, At the diagnostic assessment, the applicants are again tested on the computer, yet compared to previous ones, the applicants are to diagnose; going into the details to diagnose which are the areas that need to be addressed and then identify the support. For formative assessment, it is on going throughout the year both whether it be in lessons or at visits for WBL. Finally for summative assessment was used at the end of the unit or the whole course. It is also at the end of the unit, learners have to complete the underpinning knowledge test to prove their knowledge competence, norm referenced, criterion reference or ipsative assessment; Identify and discuss range of concepts, definitions and principles covered in learning and assessment within your professional practice In the initial assessment, computer tests are used to identify the literacy and numercacy level of potential applicants, At the diagnostic assessment, the applicants are again tested on the computer, yet compared to previous ones, the applicants are to diagnose; going into the details to diagnose which are the areas that need to be addressed and then identify support . For formative assessment, it is on going throughout the year both whether it be in lessons or at visits for WBL. Finally for summative assessment was used at the end of the unit or the whole course. It is also at the end of the unit, learners have to complete the underpinning knowledge test to prove their knowledge competence,norm referenced, criterion reference or ipsative assessment; Formal and informal assessment. I encounter informal assessment throughout the course by means ofinformal discussions and feedback; Self assessment and peer assessment Peer assessment is used more in college environment, and self assessmentis used at the end of the lessons or in tutorials Analysis of your assessment